Tolvaptan

Catalog No. A11594

Tolvaptan是一种选择性的竞争性精氨酸加压素受体2拮抗剂，IC50为1.28μM。

Technical details

Catalog Num	A11594
M. Wt	448.94
Formula	C26H25ClN2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	150683-30-0
Synonyms
SMILES	CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C

Biological Activity

Tolvaptan是一种选择性的竞争性精氨酸加压素受体2拮抗剂，IC50为1.28μM。

Targets

vasopressin receptor 2	vasopressin receptor 1a
3 nM	580 nM

Solubility *

In vitro	DMSO	81 mg/mL (180.42 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (11.13 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.27 mL	111.37 mL	222.75 mL
0.5 mM	4.45 mL	22.27 mL	44.55 mL
1 mM	2.23 mL	11.14 mL	22.27 mL
5 mM	0.45 mL	2.23 mL	4.45 mL

*The above data is based on the productmolecular weight 448.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.