YK 4-279

Catalog No. A11612

YK 4-279是与致癌转录因子EWS-FLI1结合的RNA解旋酶A（RHA）抑制剂。

Product Citations

Christopher M Schafer, .et al. An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression, Proc Natl Acad Sci U S A, 2020, Oct 20;117(42):26494-26502 PMID: 33020273

Technical details

Catalog Num	A11612
M. Wt	366.2
Formula	C17H13Cl2NO4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1037184-44-3
Synonyms	YK-4-279
SMILES	COC1=CC=C(C=C1)C(=O)CC2(C3=C(C=CC(=C3NC2=O)Cl)Cl)O

Biological Activity

YK 4-279是与致癌转录因子EWS-FLI1结合的RNA解旋酶A（RHA）抑制剂。

Targets

RNA helicase A

Solubility *

In vitro	DMSO	66 mg/mL (180.23 mM)
	Water	Insoluble
	Ethanol	Warmed: 46 mg/mL (125.61 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.31 mL	136.54 mL	273.07 mL
0.5 mM	5.46 mL	27.31 mL	54.61 mL
1 mM	2.73 mL	13.65 mL	27.31 mL
5 mM	0.55 mL	2.73 mL	5.46 mL

*The above data is based on the productmolecular weight 366.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.