Cabazitaxel

Catalog No. A11831

Cabazitaxel是一种天然紫杉烷的半合成衍生物。Cabazitaxel联合泼尼松是基于多西他赛的激素难治性前列腺癌的治疗选择。

Product Citations

Satoshi Endo, .et al. Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells, J Biochem, 2021, Mar 17 PMID: 33729485
Tomohiro Nabekura, .et al. Microtubule-targeting anticancer drug eribulin induces drug efflux transporter P-glycoprotein, Biochem Biophys Rep, 2020, Mar; 21: 100727 PMID: 31993509

Technical details

Catalog Num	A11831
M. Wt	835.93
Formula	C45H57NO14
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	183133-96-2
Synonyms	TXD-258, XRP 6258
SMILES	CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC

Biological Activity

Cabazitaxel是一种天然紫杉烷的半合成衍生物。Cabazitaxel联合泼尼松是基于多西他赛的激素难治性前列腺癌的治疗选择。

Targets

Microtubule (Cell-free assay)

Solubility *

In vitro	DMSO	91 mg/mL (108.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	11.96 mL	59.81 mL	119.63 mL
0.5 mM	2.39 mL	11.96 mL	23.93 mL
1 mM	1.2 mL	5.98 mL	11.96 mL
5 mM	0.24 mL	1.2 mL	2.39 mL

*The above data is based on the productmolecular weight 835.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.