Fluticasone propionate

Catalog No. A11860

Fluticasone propionate是一种高亲和力的选择性糖皮质激素受体激动剂（Kd = 0.5 nM）。

Product Citations

Abhinav Kumar, .et al. A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition, Pharm Res, 2017, 34(12): 2454-2465 PMID: 28560698

Technical details

Catalog Num	A11860
M. Wt	500.57
Formula	C25H31F3O5S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	80474-14-2
Synonyms	Flonase, Veramyst
SMILES	CCC(=O)O[C@@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C)C(=O)SCF

Biological Activity

Fluticasone propionate是一种高亲和力的选择性糖皮质激素受体激动剂（Kd = 0.5 nM）。

Targets

Glucocorticoid receptor

Solubility *

In vitro	DMSO	99 mg/mL (197.77 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (9.98 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.98 mL	99.89 mL	199.77 mL
0.5 mM	4 mL	19.98 mL	39.95 mL
1 mM	2 mL	9.99 mL	19.98 mL
5 mM	0.4 mL	2 mL	4 mL

*The above data is based on the productmolecular weight 500.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.