Lamotrigine

Catalog No. A11873

Lamotrigine是一种新型抗惊厥药剂，在人血小板和大鼠脑突触小体中抑制5-HT的IC50为240μM和474μM，并且是钠通道阻滞剂。

Technical details

Catalog Num	A11873
M. Wt	256.09
Formula	C9H7Cl2N5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	84057-84-1
Synonyms
SMILES	C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N

Biological Activity

Lamotrigine是一种新型抗惊厥药剂，在人血小板和大鼠脑突触小体中抑制5-HT的IC50为240μM和474μM，并且是钠通道阻滞剂。

Targets

Sodium channel	5-HT (human platelets)	5-HT (rat brain synaptosomes)
N/A	240 μM	474 μM

Solubility *

In vitro (25°C)	DMSO	9 mg/mL (35.14 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (11.71 mM)
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	39.05 mL	195.24 mL	390.49 mL
0.5 mM	7.81 mL	39.05 mL	78.1 mL
1 mM	3.9 mL	19.52 mL	39.05 mL
5 mM	0.78 mL	3.9 mL	7.81 mL

*The above data is based on the productmolecular weight 256.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.