Lovastatin (Mevacor)

Catalog No. A11877

Lovastatin (Mevacor)是HMG-CoA还原酶的抑制剂，IC50为3.4 nM，用于降低胆固醇。

Technical details

Catalog Num	A11877
M. Wt	404.54
Formula	C24H36O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	75330-75-5
Synonyms
SMILES	CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C

Biological Activity

Lovastatin (Mevacor)是HMG-CoA还原酶的抑制剂，IC50为3.4 nM，用于降低胆固醇。

Targets

HMG-CoA reductase (Cell-free assay)
3.4 nM

Solubility *

In vitro (25°C)	DMSO	7 mg/mL (17.3 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (12.36 mM)
In vivo	5% DMSO+40%PEG 300+ 5% Tween80 + 50% ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.72 mL	123.6 mL	247.19 mL
0.5 mM	4.94 mL	24.72 mL	49.44 mL
1 mM	2.47 mL	12.36 mL	24.72 mL
5 mM	0.49 mL	2.47 mL	4.94 mL

*The above data is based on the productmolecular weight 404.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.