RITA (NSC 652287)

Catalog No. A11931

RITA，也称为NSC 652287，是一种三环噻吩衍生物，与MDM2结合，破坏MDM2-p53复合物，随后激活p53，并诱导凋亡。

Product Citations

M Kobayashi, .et al. Nutlin-3a Suppresses Poly (ADP-ribose) Polymerase 1 by Mechanisms Different From Conventional PARP1 Suppressors in a Human Breast Cancer Cell Line, Oncotarget, 2020, May 5;11(18):1653-1665 PMID: 32405340

Technical details

Catalog Num	A11931
M. Wt	292.4
Formula	C14H12O3S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	213261-59-7
Synonyms	NSC652287, p53 Activator III
SMILES	C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO

Biological Activity

RITA，也称为NSC 652287，是一种三环噻吩衍生物，与MDM2结合，破坏MDM2-p53复合物，随后激活p53，并诱导凋亡。

Targets

Mdm2	p53

Solubility *

In vitro (25°C)	DMSO	56 mg/mL (191.53 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (27.36 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.2 mL	171 mL	342 mL
0.5 mM	6.84 mL	34.2 mL	68.4 mL
1 mM	3.42 mL	17.1 mL	34.2 mL
5 mM	0.68 mL	3.42 mL	6.84 mL

*The above data is based on the productmolecular weight 292.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.