GW2580
Catalog No. A11959
GW2580是cFMS激酶的小分子，ATP竞争性抑制剂。
- Ravikanth Maddipati, .et al. MYC controls metastatic heterogeneity in pancreatic cancer, bioRxiv, 2021, February 01
- Liu M, .et al. Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal, Nat Immunol, 2019, Jan 21 PMID: 30664738
| Catalog Num | A11959 |
|---|---|
| M. Wt | 366.41 |
| Formula | C20H22N4O3 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 870483-87-7 |
| Synonyms | GW 2580, GW-2580 |
| SMILES | COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC |
GW2580是cFMS激酶的小分子，ATP竞争性抑制剂。
| In vitro (25°C) | DMSO | 48 mg/mL (131 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.29 mL | 136.46 mL | 272.92 mL |
| 0.5 mM | 5.46 mL | 27.29 mL | 54.58 mL |
| 1 mM | 2.73 mL | 13.65 mL | 27.29 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
*The above data is based on the productmolecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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