GW9508

Catalog No. A11965

GW 9508是一种可透过细胞的氨基苯基丙酸酯，可作为G蛋白偶联受体（GPCR）GRP40/FFA1受体（EC50?50 nM）的有效选择性激动剂，对家族成员GRP120的活性降低（EC50?3.5μM），GRP41/GRP43（EC50> 50μM），以及一组八种其他游离脂肪酸（FFA）和前列腺素受体。

Technical details

Catalog Num	A11965
M. Wt	347.4
Formula	C22H21NO3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	885101-89-3
Synonyms	GW 9508, GW-9508
SMILES	C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O

Biological Activity

Targets

GPR40	GPR120
7.32(pEC50)	5.46(pEC50)

Solubility *

In vitro (25°C)	DMSO	63 mg/mL (181.34 mM)
	Water	Insoluble
	Ethanol	63 mg/mL (181.34 mM)
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.79 mL	143.93 mL	287.85 mL
0.5 mM	5.76 mL	28.79 mL	57.57 mL
1 mM	2.88 mL	14.39 mL	28.79 mL
5 mM	0.58 mL	2.88 mL	5.76 mL

*The above data is based on the productmolecular weight 347.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.