TCS PIM-1 4a (SMI-4a)

Catalog No. A11967

TCS PIM-1 4a (SMI-4a)是一种具有选择性和ATP竞争性的Pim激酶抑制剂（Pim-1和Pim-2的IC50值分别为24和100 nM）。

Technical details

Catalog Num	A11967
M. Wt	273.23
Formula	C11H6F3NO2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	438190-29-5
Synonyms	0
SMILES	O=C(NC/1=O)SC1=C\C2=CC=CC(C(F)(F)F)=C2

Biological Activity

TCS PIM-1 4a (SMI-4a)是一种具有选择性和ATP竞争性的Pim激酶抑制剂（Pim-1和Pim-2的IC50值分别为24和100 nM）。

Targets

Pim1
17 nM

Solubility *

In vitro (25°C)	DMSO	47 mg/mL (172.01 mM)
	Water	Insoluble
	Ethanol	28 mg/mL (102.47 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	36.6 mL	183 mL	365.99 mL
0.5 mM	7.32 mL	36.6 mL	73.2 mL
1 mM	3.66 mL	18.3 mL	36.6 mL
5 mM	0.73 mL	3.66 mL	7.32 mL

*The above data is based on the productmolecular weight 273.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.