Necrostatin-1

Catalog No. A11973

Necrostatin-1是一种与ATP竞争的，与受体相互作用的蛋白激酶1（RIPK1）的变构抑制剂（EC50 = 182 nM）。

Technical details

Catalog Num	A11973
M. Wt	259.33
Formula	C13H13N3OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	4311-88-0
Synonyms
SMILES	CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32

Biological Activity

Necrostatin-1是一种与ATP竞争的，与受体相互作用的蛋白激酶1（RIPK1）的变构抑制剂（EC50 = 182 nM）。

Targets

RIP1 (293T cells)
490 nM(EC50)

Solubility *

In vitro (25°C)	DMSO	Warmed: 43 mg/mL (165.81 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+45% PEG 300+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	38.56 mL	192.8 mL	385.61 mL
0.5 mM	7.71 mL	38.56 mL	77.12 mL
1 mM	3.86 mL	19.28 mL	38.56 mL
5 mM	0.77 mL	3.86 mL	7.71 mL

*The above data is based on the productmolecular weight 259.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.