Amprenavir

Catalog No. A11985

Amprenavir是一种人类免疫缺陷病毒（HIV）蛋白酶抑制剂，对于野生型HIV分离株，IC50为14.6±12.5 ng/ml。

Product Citations

Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967

Technical details

Catalog Num	A11985
M. Wt	505.63
Formula	C25H35N3O6S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	161814-49-9
Synonyms
SMILES	CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CCOC2)O)S(=O)(=O)C3=CC=C(C=C3)N

Biological Activity

Amprenavir是一种人类免疫缺陷病毒（HIV）蛋白酶抑制剂，对于野生型HIV分离株，IC50为14.6±12.5 ng/ml。

Targets

PXR	HIV protease
N/A	14.6 ng/mL

Solubility *

In vitro	DMSO	15 mg/mL (29.66 mM)
	Water	Insoluble
	Ethanol	91 mg/mL (179.97 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.78 mL	98.89 mL	197.77 mL
0.5 mM	3.96 mL	19.78 mL	39.55 mL
1 mM	1.98 mL	9.89 mL	19.78 mL
5 mM	0.4 mL	1.98 mL	3.96 mL

*The above data is based on the productmolecular weight 505.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.