Sirtinol

Catalog No. A12226

Sirtinol是Sirtinol NAD依赖组蛋白去乙酰化酶的细胞渗透性特异性抑制剂。在无细胞分析中，它是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。

Technical details

Catalog Num	A12226
M. Wt	394.47
Formula	C26H22N2O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	410536-97-9
Synonyms	Sir Two Inhibitor Naphthol
SMILES	O=C(N([H])C(C1=CC=CC=C1)C)C(C=CC=C2)=C2/N=C/C3=C(O)C=CC4=C3C=CC=C4

Biological Activity

Sirtinol是Sirtinol NAD依赖组蛋白去乙酰化酶的细胞渗透性特异性抑制剂。在无细胞分析中，它是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。

Solubility *

In vitro (25°C)	DMSO	20 mg/mL (50.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	0.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.35 mL	126.75 mL	253.5 mL
0.5 mM	5.07 mL	25.35 mL	50.7 mL
1 mM	2.54 mL	12.68 mL	25.35 mL
5 mM	0.51 mL	2.54 mL	5.07 mL

*The above data is based on the productmolecular weight 394.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Sirtinol

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions