NMS-873

Catalog No. A12377

NMS-873是一种有效且特异的ATPase VCP/p97小分子变构抑制剂（IC50?0.03 uM），通过高通量筛选得以鉴定。

Product Citations

Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7

Technical details

Catalog Num	A12377
M. Wt	520.67
Formula	C27H28N4O3S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1418013-75-8
Synonyms	NMS873, NMS 873
SMILES	CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C

Biological Activity

NMS-873是一种有效且特异的ATPase VCP/p97小分子变构抑制剂（IC50?0.03 uM），通过高通量筛选得以鉴定。

Targets

p97
30 nM

Solubility *

In vitro	DMSO	98 mg/mL (188.22 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.21 mL	96.03 mL	192.06 mL
0.5 mM	3.84 mL	19.21 mL	38.41 mL
1 mM	1.92 mL	9.6 mL	19.21 mL
5 mM	0.38 mL	1.92 mL	3.84 mL

*The above data is based on the productmolecular weight 520.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.