Go 6976

Catalog No. A12419

Go6976是一种有效的PKC抑制剂，对PKC（大鼠脑），PKCα和PKCβ1的IC50分别为7.9 nM，2.3 nM和6.2 nM。也是JAK2和Flt3的有效抑制剂。

Technical details

Catalog Num	A12419
M. Wt	378.43
Formula	C24H18N4O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	136194-77-9
Synonyms	Go6976, Go-6976
SMILES	CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O

Biological Activity

Go6976是一种有效的PKC抑制剂，对PKC（大鼠脑），PKCα和PKCβ1的IC50分别为7.9 nM，2.3 nM和6.2 nM。也是JAK2和Flt3的有效抑制剂。

Targets

JAK2	FLT3	PKCα	PKCβ1	PKC (Rat brain)
N/A		2.3 nM	6.2 nM	7.9 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 18 mg/mL (47.69 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC Na+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.42 mL	132.12 mL	264.25 mL
0.5 mM	5.28 mL	26.42 mL	52.85 mL
1 mM	2.64 mL	13.21 mL	26.42 mL
5 mM	0.53 mL	2.64 mL	5.28 mL

*The above data is based on the productmolecular weight 378.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.