EPZ005687

Catalog No. A12439

EPZ005687是EZH2的有效抑制剂 (Ki为24 nM)。

Technical details

Catalog Num	A12439
M. Wt	539.67
Formula	C32H37N5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1396772-26-1
Synonyms	EPZ-005687
SMILES	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC=C(C=C4)CN5CCOCC5)C6CCCC6)C

Biological Activity

EPZ005687是EZH2的有效抑制剂 (Ki为24 nM)。

Targets

EZH2 (Cell-free assay)
24 nM(Ki)

Solubility *

In vitro	DMSO	2 mg/mL (3.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.53 mL	92.65 mL	185.3 mL
0.5 mM	3.71 mL	18.53 mL	37.06 mL
1 mM	1.85 mL	9.26 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL

*The above data is based on the productmolecular weight 539.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.