Halofuginone

Catalog No. A12441

Halofuginone是来源于常山植物的半合成喹唑啉酮生物碱抗球虫药，具有抗纤维化和潜在的抗肿瘤活性。

Product Citations

Satoshi Endo, .et al. Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells, J Biochem, 2021, Mar 17 PMID: 33729485

Technical details

Catalog Num	A12441
M. Wt	414.68
Formula	C16H17BrClN3O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	55837-20-2
Synonyms	Tempostatin; RU 19110
SMILES	C1C[C@H]([C@@H](NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O

Biological Activity

Halofuginone是来源于常山植物的半合成喹唑啉酮生物碱抗球虫药，具有抗纤维化和潜在的抗肿瘤活性。

Targets

prolyl-tRNA synthetase
18.3nM(Ki)

Solubility *

In vitro	DMSO	17 mg/mL (40.99 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.11 mL	120.57 mL	241.15 mL
0.5 mM	4.82 mL	24.11 mL	48.23 mL
1 mM	2.41 mL	12.06 mL	24.11 mL
5 mM	0.48 mL	2.41 mL	4.82 mL

*The above data is based on the productmolecular weight 414.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.