BI-D1870

Catalog No. A12452

BI-D1870是体外和体内p90核糖体S6激酶（RSK）亚型的有效特异性抑制剂，在体外抑制RSK1，RSK2，RSK3和RSK4的IC50为10–30 nM。

Product Citations

Yuan Xiao Zhu, etc. RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2. Blood. 2015 Jan 15; 125(3): 483–491.

Technical details

Catalog Num	A12452
M. Wt	391.41
Formula	C19H23F2N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	501437-28-1
Synonyms
SMILES	CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C

Biological Activity

BI-D1870是体外和体内p90核糖体S6激酶（RSK）亚型的有效特异性抑制剂，在体外抑制RSK1，RSK2，RSK3和RSK4的IC50为10–30 nM。

Targets

RSK4 (Cell-free assay)	RSK3 (Cell-free assay)	RSK2 (Cell-free assay)	RSK1 (Cell-free assay)
15 nM	18 nM	24 nM	31 nM

Solubility *

In vitro (25°C)	DMSO	71 mg/mL (181.39 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.55 mL	127.74 mL	255.49 mL
0.5 mM	5.11 mL	25.55 mL	51.1 mL
1 mM	2.55 mL	12.77 mL	25.55 mL
5 mM	0.51 mL	2.55 mL	5.11 mL

*The above data is based on the productmolecular weight 391.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.