BAY 11-7085

Catalog No. A12470

BAY 11-7085是TNFα诱导的IκBα磷酸化的不可逆抑制剂，IC50为10μM。

Product Citations

Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055

Technical details

Catalog Num	A12470
M. Wt	249.33
Formula	C13H15NO2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	196309-76-9
Synonyms	Bay 11-7083, BAY11-7085
SMILES	CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)/C=C/C#N

Biological Activity

BAY 11-7085是TNFα诱导的IκBα磷酸化的不可逆抑制剂，IC50为10μM。

Targets

IκBα?phosphorylation
10 μM

Solubility *

In vitro	DMSO	49 mg/mL (196.52 mM)
	Water	Insoluble
	Ethanol	49 mg/mL (196.52 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	40.11 mL	200.54 mL	401.07 mL
0.5 mM	8.02 mL	40.11 mL	80.21 mL
1 mM	4.01 mL	20.05 mL	40.11 mL
5 mM	0.8 mL	4.01 mL	8.02 mL

*The above data is based on the productmolecular weight 249.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.