VS-5584

Catalog No. A12480

VS-5584是一种新型且高度选择性的PI3K/mTOR激酶抑制剂，可用于治疗癌症。

Technical details

Catalog Num	A12480
M. Wt	354.41
Formula	C17H22N8O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1246560-33-7
Synonyms	SB2343, VS5584, SB-2343, SB 2343
SMILES	CC1=NC2=C(N=C(N=C2N1C(C)C)N3CCOCC3)C4=CN=C(N=C4)N

Biological Activity

VS-5584是一种新型且高度选择性的PI3K/mTOR激酶抑制剂，可用于治疗癌症。

Targets

PI3Kα	PI3Kδ	PI3Kγ	mTOR	PI3Kβ
2.6 nM	2.7 nM	3.0 nM	3.4 nM	21 nM

Solubility *

In vitro (25°C)	DMSO	70 mg/mL (197.51 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (8.46 mM)
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.22 mL	141.08 mL	282.16 mL
0.5 mM	5.64 mL	28.22 mL	56.43 mL
1 mM	2.82 mL	14.11 mL	28.22 mL
5 mM	0.56 mL	2.82 mL	5.64 mL

*The above data is based on the productmolecular weight 354.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.