Perampanel

Catalog No. A12498

Perampanel是一种选择性的非竞争性AMPA型谷氨酸受体拮抗剂，在实验性癫痫发作模型中表现出抗惊厥活性，在临床试验中表现出抗癫痫活性。

Product Citations

Ashwin J. Mali, .et al. Investigation of polyvinyl alcohol-polyethylene glycol graft copolymer as an advanced functional polymer in the development of perampanel orodispersible film, Journal of Polymer Research, 2022, 29, 130
Fumihiro Kawakita, .et al. Inhibition of AMPA (α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate) Receptor Reduces Acute Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice, Transl Stroke Res, 2021, Aug 3 PMID: 34342874
Citlalli Netzahualcoyotzi, .et al. Neuronal and astroglial monocarboxylate transporters play key but distinct roles in hippocampus-dependent learning and memory formation, Prog Neurobiol, 2020, Jul 18;101888 PMID: 32693190
Bostwick M, .et al. Antagonistic Inhibitory Circuits Integrate Visual and Gravitactic Behaviors, Curr Biol, 2020, Feb 24;30(4):600-609 PMID: 32008899
HS Venkatesh, .et al. Electrical and synaptic integration of glioma into neural circuits, Nature, 2019, 573:539-545 PMID: 31534222
Nozawa A, .et al. Perampanel Inhibits Neuroblastoma Cell Proliferation Through Down-regulation of AKT and ERK Pathways, Anticancer Res, 2019, 39(7): 3595-3599 PMID: 31262884
Matthew Kourakis, .et al. Parallel Visual Circuitry in a Basal Chordate, bioRxiv, 2019, Jan. 8 2019

Technical details

Catalog Num	A12498
M. Wt	349.38
Formula	C23H15N3O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	380917-97-5
Synonyms
SMILES	C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4

Biological Activity

Perampanel是一种选择性的非竞争性AMPA型谷氨酸受体拮抗剂，在实验性癫痫发作模型中表现出抗惊厥活性，在临床试验中表现出抗癫痫活性。

Targets

AMPA glutamate receptor

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.62 mL	143.11 mL	286.22 mL
0.5 mM	5.72 mL	28.62 mL	57.24 mL
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL

*The above data is based on the productmolecular weight 349.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.