(E/Z)-4-hydroxy Tamoxifen

Catalog No. A12532

(E/Z)-4-hydroxy Tamoxifen是他莫昔芬的活性代谢产物，是一种选择性雌激素受体（ER）调节剂，广泛用于乳腺癌的治疗和化学预防治疗。

Product Citations

Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347

Technical details

Catalog Num	A12532
M. Wt	387.51
Formula	C26H29NO2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	68392-35-8
Synonyms	Afimoxifene
SMILES	OC1=CC=C(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)/CC)C=C1

Biological Activity

(E/Z)-4-hydroxy Tamoxifen是他莫昔芬的活性代谢产物，是一种选择性雌激素受体（ER）调节剂，广泛用于乳腺癌的治疗和化学预防治疗。

Solubility *

In vitro	DMSO	72 mg/mL (185.8 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.81 mL	129.03 mL	258.06 mL
0.5 mM	5.16 mL	25.81 mL	51.61 mL
1 mM	2.58 mL	12.9 mL	25.81 mL
5 mM	0.52 mL	2.58 mL	5.16 mL

*The above data is based on the productmolecular weight 387.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.