PF 4981517

Catalog No. A12544

PF 4981517是一种有效且选择性的CYP3A4抑制剂（CYP3A4，CYP3A5和CYP3A7的IC50值分别为0.03、17和70 μM）。

Technical details

Catalog Num	A12544
M. Wt	456.59
Formula	C26H32N8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1390637-82-7
Synonyms	PF4981517, PF-4981517
SMILES	CC1=CC=C(C=C1)C2=C(C=NN2C)C3=NN(C4=C3C(=NC=N4)N5CC[C@@H](C5)N6CCCCC6)C

Biological Activity

PF 4981517是一种有效且选择性的CYP3A4抑制剂（CYP3A4，CYP3A5和CYP3A7的IC50值分别为0.03、17和70 μM）。

Targets

CYP3A4
30 nM

Solubility *

In vitro	DMSO	85 mg/mL (186.16 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.9 mL	109.51 mL	219.01 mL
0.5 mM	4.38 mL	21.9 mL	43.8 mL
1 mM	2.19 mL	10.95 mL	21.9 mL
5 mM	0.44 mL	2.19 mL	4.38 mL

*The above data is based on the productmolecular weight 456.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.