Selinexor (KPT-330)

Catalog No. A12582

CRM1（XPO1）介导的核输出的KPT-330抑制剂在T细胞急性淋巴细胞白血病和急性骨髓性白血病的临床前模型中具有选择性的抗白血病活性。

Product Citations

Chie Ishikawa, .et al. Exportin-1 is critical for cell proliferation and survival in adult T cell leukemia, Invest New Drugs, 2022, Aug;40(4):718-727 PMID: 35477814

Technical details

Catalog Num	A12582
M. Wt	443.31
Formula	C17H11F6N7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1393477-72-9
Synonyms	KPT330, KPT 330
SMILES	C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F

Biological Activity

CRM1（XPO1）介导的核输出的KPT-330抑制剂在T细胞急性淋巴细胞白血病和急性骨髓性白血病的临床前模型中具有选择性的抗白血病活性。

Targets

CRM1 (Cell-free assay)

Solubility *

In vitro (25°C)	DMSO	78 mg/mL (175.94 mM)
	Water	Insoluble
	Ethanol	36 mg/mL (81.21 mM)
In vivo	2% DMSO+40%PEG 300+5% Tween80 +ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.56 mL	112.79 mL	225.58 mL
0.5 mM	4.51 mL	22.56 mL	45.12 mL
1 mM	2.26 mL	11.28 mL	22.56 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

*The above data is based on the productmolecular weight 443.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.