MPEP

Catalog No. A12589

MPEP是mGlu5受体亚型（IC50 = 36 nM）的有效且高度选择性的非竞争性拮抗剂，并且是mGlu4受体的正构构调节剂。

Technical details

Catalog Num	A12589
M. Wt	193.249
Formula	C14H11N
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	96206-92-7
Synonyms
SMILES	CC1=CC=CC(=N1)C#CC2=CC=CC=C2

Biological Activity

MPEP是mGlu5受体亚型（IC50 = 36 nM）的有效且高度选择性的非竞争性拮抗剂，并且是mGlu4受体的正构构调节剂。

Targets

mGluR5
36 nM

Solubility *

In vitro (25°C)	DMSO	36 mg/mL (186.3 mM)
	Water	Insoluble
	Ethanol	36 mg/mL (186.3 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	51.75 mL	258.73 mL	517.47 mL
0.5 mM	10.35 mL	51.75 mL	103.49 mL
1 mM	5.17 mL	25.87 mL	51.75 mL
5 mM	1.03 mL	5.17 mL	10.35 mL

*The above data is based on the productmolecular weight 193.249. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.