Salubrinal

Catalog No. A12676

Salubrinal是细胞磷酸酶复合物的可渗透细胞的选择性抑制剂，可将真核翻译起始因子2亚基α（eIF2α）磷酸化。保护细胞免受内质网应激诱导的细胞凋亡（EC50?15 μM）。

Product Citations

Gregory R. Kardos, .et al. Salubrinal in Combination With 4E1RCat Synergistically Impairs Melanoma Development by Disrupting the Protein Synthetic Machinery, Front Oncol, 2020, 10: 834 PMID: 32637352

Technical details

Catalog Num	A12676
M. Wt	479.81
Formula	C21H17N4OSCl3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	405060-95-9
Synonyms
SMILES	C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3

Biological Activity

Targets

eIF2α (Cell-free assay)

Solubility *

In vitro	DMSO	86 mg/mL (179.23 mM)
	Water	Insoluble
	Ethanol	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.84 mL	104.21 mL	208.42 mL
0.5 mM	4.17 mL	20.84 mL	41.68 mL
1 mM	2.08 mL	10.42 mL	20.84 mL
5 mM	0.42 mL	2.08 mL	4.17 mL

*The above data is based on the productmolecular weight 479.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.