PD168393

Catalog No. A12725

PD168393是一种有效的，细胞可渗透的，不可逆的EGFR抑制剂，IC50值为700 pM。

Technical details

Catalog Num	A12725
M. Wt	369.22
Formula	C17H13BrN4O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	194423-15-9
Synonyms	PD-168393, PD 168393
SMILES	C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br

Biological Activity

PD168393是一种有效的，细胞可渗透的，不可逆的EGFR抑制剂，IC50值为700 pM。

Targets

EGFR	Insulin Receptor	PDGFR	FGFR	PKC
0.70 nM	>50 μM	>50 μM	>50 μM	>50 μM

Solubility *

In vitro (25°C)	DMSO	72 mg/mL (195 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.08 mL	135.42 mL	270.84 mL
0.5 mM	5.42 mL	27.08 mL	54.17 mL
1 mM	2.71 mL	13.54 mL	27.08 mL
5 mM	0.54 mL	2.71 mL	5.42 mL

*The above data is based on the productmolecular weight 369.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.