AMG517

Catalog No. A12727

AMG 517是有效的选择性TRPV1拮抗剂。

Product Citations

Jun Hai, .et al. Intragastric administration of AMG517, a TRPV1 antagonist, enhanced activity-dependent energy metabolism via capsaicin-sensitive sensory nerves in mice, Biosci Biotechnol Biochem, 2020, Jul 7;1-7 PMID: 32633621
Hai J, .et al. Differences in the effects of TRPV1 antagonists on energy metabolism in mice, Biomed Res, 2018, 39(6):279-286 PMID: 30531157

Technical details

Catalog Num	A12727
M. Wt	430.4
Formula	C20H13F3N4O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	659730-32-2
Synonyms	AMG 517, AMG-517
SMILES	CC(=O)NC1=NC2=C(C=CC=C2S1)OC3=NC=NC(=C3)C4=CC=C(C=C4)C(F)(F)F

Biological Activity

AMG 517是有效的选择性TRPV1拮抗剂。

Targets

TRPV1
1 nM-2 nM

Solubility *

In vitro (25°C)	DMSO	84 mg/mL (195.16 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	10% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.23 mL	116.17 mL	232.34 mL
0.5 mM	4.65 mL	23.23 mL	46.47 mL
1 mM	2.32 mL	11.62 mL	23.23 mL
5 mM	0.46 mL	2.32 mL	4.65 mL

*The above data is based on the productmolecular weight 430.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.