PF-5274857

Catalog No. A12775

PF-5274857是一种新型Smo拮抗剂，它以4.6±1.1 nmol/L的K（i）特异性结合Smo，并以2.7±1.4 nmol/L的IC（50）完全阻断下游基因Gli1的转录活性。在细胞中。

Technical details

Catalog Num	A12775
M. Wt	436.96
Formula	C20H25ClN4O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1373615-35-0
Synonyms	PF5274857, PF 5274857
SMILES	CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C

Biological Activity

PF-5274857是一种新型Smo拮抗剂，它以4.6±1.1 nmol/L的K（i）特异性结合Smo，并以2.7±1.4 nmol/L的IC（50）完全阻断下游基因Gli1的转录活性。在细胞中。

Targets

Smoothened	Smoothened
4.6 nM(Ki)	5.8 nM

Solubility *

In vitro (25°C)	DMSO	83 mg/mL (189.95 mM)
	Water	83 mg/mL (189.95 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.89 mL	114.43 mL	228.85 mL
0.5 mM	4.58 mL	22.89 mL	45.77 mL
1 mM	2.29 mL	11.44 mL	22.89 mL
5 mM	0.46 mL	2.29 mL	4.58 mL

*The above data is based on the productmolecular weight 436.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.