AZD1080

Catalog No. A12819

AZD1080是一种新型GSK3抑制剂，可消除啮齿动物大脑中的突触可塑性缺陷，并在人类中表现出外周靶标参与。

Product Citations

Shengzhong Liu, .et al. STAT1-avtiviated LINC00961 regulates myocardial infarction by the PI3K/AKT/GSK3?? signaling pathway, J Cell Biochem, 2019, 2019

Technical details

Catalog Num	A12819
M. Wt	334.4
Formula	C19H18N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	612487-72-6
Synonyms	AZD 1080, AZD-1080
SMILES	C1COCCN1CC2=CN/C(=C\3/C4=C(C=CC(=C4)C#N)NC3=O)/C=C2

Biological Activity

AZD1080是一种新型GSK3抑制剂，可消除啮齿动物大脑中的突触可塑性缺陷，并在人类中表现出外周靶标参与。

Targets

GSK-3α	GSK-3β
6.9 nM	31 nM

Solubility *

In vitro (25°C)	DMSO	49 mg/mL (146.54 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.9 mL	149.52 mL	299.04 mL
0.5 mM	5.98 mL	29.9 mL	59.81 mL
1 mM	2.99 mL	14.95 mL	29.9 mL
5 mM	0.6 mL	2.99 mL	5.98 mL

*The above data is based on the productmolecular weight 334.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.