Sabutoclax

Catalog No. A12823

Sabutoclax (BI-97C1)是pan-Bcl-2抑制剂，包括Bcl-xL，Bcl-2，Mcl-1和Bfl-1，IC50分别为0.31 μM，0.32 μM，0.20 μM和0.62 μM。

Product Citations

Christopher D. Graham, .et al. BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells, Oncotarget, 2017, Jan 31; 8(5): 8670-8678 PMID: 28055968

Technical details

Catalog Num	A12823
M. Wt	700.78
Formula	C42H40N2O8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1228108-65-3
Synonyms	BI-97C1,BI97C1
SMILES	CC1=C(C(=C2C=C(C(=C(C2=C1)C(=O)NC[C@H](C)C3=CC=CC=C3)O)O)O)C4=C(C=C5C(=C4O)C=C(C(=C5C(=O)NC[C@H](C)C6=CC=CC=C6)O)O)C

Biological Activity

Sabutoclax (BI-97C1)是pan-Bcl-2抑制剂，包括Bcl-xL，Bcl-2，Mcl-1和Bfl-1，IC50分别为0.31 μM，0.32 μM，0.20 μM和0.62 μM。

Targets

Mcl-1	Bcl-xL	Bcl-2	Bfl-1
0.20 μM	0.31 μM	0.32 μM	0.62 μM

Solubility *

In vitro	DMSO	Warmed: 93 mg/mL (132.7 mM)
	Water	Insoluble
	Ethanol	Warmed: 50 mg/mL (71.34 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.27 mL	71.35 mL	142.7 mL
0.5 mM	2.85 mL	14.27 mL	28.54 mL
1 mM	1.43 mL	7.13 mL	14.27 mL
5 mM	0.29 mL	1.43 mL	2.85 mL

*The above data is based on the productmolecular weight 700.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.