HSP-990
Catalog No. A12850
HSP990是人热休克蛋白90(Hsp90)的口服生物利用抑制剂,对HSP90α/β的IC50分别为0.6 nM和0.8 nM。具有潜在的抗肿瘤活性。
- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
Catalog Num | A12850 |
---|---|
M. Wt | 379.39 |
Formula | C20H18FN5O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 934343-74-5 |
Synonyms | HSP990, HSP 990, NVP-HSP990 |
SMILES | CC1=NC(=NC2=C1C(=O)N[C@H](C2)C3=C(C=C(C=C3)F)C4=NC(=CC=C4)OC)N |
HSP990是人热休克蛋白90(Hsp90)的口服生物利用抑制剂,对HSP90α/β的IC50分别为0.6 nM和0.8 nM。具有潜在的抗肿瘤活性。
Targets
HSP90α | HSP90β | |||
0.6 nM | 0.8 nM |
In vitro | DMSO | 65 mg/mL (171.32 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 26.36 mL | 131.79 mL | 263.58 mL |
0.5 mM | 5.27 mL | 26.36 mL | 52.72 mL |
1 mM | 2.64 mL | 13.18 mL | 26.36 mL |
5 mM | 0.53 mL | 2.64 mL | 5.27 mL |
*The above data is based on the productmolecular weight 379.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.