Delamanid (OPC-67683)

Catalog No. A12864

Delamanid (OPC-67683)是一种新的抗结核药物，它抑制霉菌酸的合成，并已显示出对结核分枝杆菌耐药菌株的有效的体外和体内活性。

Product Citations

Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
World Health Organization, .et al. Technical manual for drug susceptibility testing of medicines used in the treatment of tuberculosis, World Health Organization, 2018, WHO/CDS/TB/2018.24

Technical details

Catalog Num	A12864
M. Wt	534.48
Formula	C25H25F3N4O6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	681492-22-8
Synonyms
SMILES	C[C@@]1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F

Biological Activity

Delamanid (OPC-67683)是一种新的抗结核药物，它抑制霉菌酸的合成，并已显示出对结核分枝杆菌耐药菌株的有效的体外和体内活性。

Solubility *

In vitro	DMSO	85 mg/mL (159.03 mM)
	Water	Insoluble
	Ethanol	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.71 mL	93.55 mL	187.1 mL
0.5 mM	3.74 mL	18.71 mL	37.42 mL
1 mM	1.87 mL	9.35 mL	18.71 mL
5 mM	0.37 mL	1.87 mL	3.74 mL

*The above data is based on the productmolecular weight 534.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.