PF-4989216

Catalog No. A12889

PF-4989216是一种有效的选择性PI3K抑制剂，对p110α，p110β，p110γ，p110δ和VPS34的IC50分别为2 nM，142 nM，65 nM，1 nM和110 nM。

Technical details

Catalog Num	A12889
M. Wt	380.4
Formula	C18H13FN6OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1276553-09-3
Synonyms	PF4989216, PF 4989216
SMILES	C1COCCN1C2=C(C(=C(S2)C3=NC=NN3)C4=C(C=C(C=C4)C#N)F)C#N

Biological Activity

PF-4989216是一种有效的选择性PI3K抑制剂，对p110α，p110β，p110γ，p110δ和VPS34的IC50分别为2 nM，142 nM，65 nM，1 nM和110 nM。

Targets

p110δ	p110α	p110γ	Vps34	p110β
1 nM	2 nM	65 nM	110 nM	142 nM

Solubility *

In vitro (25°C)	DMSO	66 mg/mL (173.49 mM)
	Water	Insoluble
	Ethanol	Warmed: 6 mg/mL (15.77 mM)
In vivo	Suspended in 0.5% methylcellulose	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.29 mL	131.44 mL	262.88 mL
0.5 mM	5.26 mL	26.29 mL	52.58 mL
1 mM	2.63 mL	13.14 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

*The above data is based on the productmolecular weight 380.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.