Forskolin

Catalog No. A12917

Forskolin是具有抗高血压，正性肌力和腺苷酸环化酶激活特性的细胞渗透性二萜。Forskolin 是一种有效的腺苷酸环化酶激活剂，结合到 I 型腺苷酸环化酶 IC50 为 41 nM，激活 I 型腺苷酸环化酶 EC50 为 0.5 μM。

Technical details

Catalog Num	A12917
M. Wt	410.51
Formula	C22H34O7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	66575-29-9
Synonyms	Coleonol, Colforsin
SMILES	CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O

Biological Activity

Targets

Adenylyl cyclase (AC) (A wide variety of cell types)

Solubility *

In vitro	DMSO	72 mg/mL (175.39 mM)
	Water	Insoluble
	Ethanol	33 mg/mL (80.39 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.36 mL	121.8 mL	243.6 mL
0.5 mM	4.87 mL	24.36 mL	48.72 mL
1 mM	2.44 mL	12.18 mL	24.36 mL
5 mM	0.49 mL	2.44 mL	4.87 mL

*The above data is based on the productmolecular weight 410.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.