P 22077

Catalog No. A12933

P 22077是泛素特异性蛋白酶(EC50 = 8.6 μM)和密切相关的双酶usp47。

Technical details

Catalog Num	A12933
M. Wt	315.32
Formula	C12H7F2NO3S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1247819-59-5
Synonyms	P22077
SMILES	CC(=O)C1=CC(=C(S1)SC2=C(C=C(C=C2)F)F)[N+](=O)[O-]

Biological Activity

P 22077是泛素特异性蛋白酶(EC50 = 8.6 μM)和密切相关的双酶usp47。

Targets

Target	Value
USP7	EC50	8.6μM
USP47	EC50	8.74μM
USP2core	EC50	>50μM
USP4	EC50	>50μM
USP5	EC50	>50μM
USP8	EC50	>50μM
USP15	EC50	>50μM
USP20	EC50	>50μM
USP28	EC50	>50μM
JOSD2	EC50	>50μM
UCH-L1	EC50	>50μM
UCH-L3	EC50	>50μM
UCH-L5	EC50	>50μM
DEN1	EC50	>50μM
Plpro	EC50	>50μM
SENP6core	EC50	>50μM
PLA2	EC50	>50μM
Calpain1	EC50	>50μM
CT-L	EC50	>50μM
CathepsinD	EC50	>50μM
MMP13	EC50	>50μM
Trypsin	EC50	>50μM

Solubility *

In vitro (25°C)	DMSO	57 mg/mL (180.76 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.71 mL	158.57 mL	317.14 mL
0.5 mM	6.34 mL	31.71 mL	63.43 mL
1 mM	3.17 mL	15.86 mL	31.71 mL
5 mM	0.63 mL	3.17 mL	6.34 mL

*The above data is based on the productmolecular weight 315.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.