SGC 0946

Catalog No. A12941

SGC 0946是有效的DOT1L甲基转移酶抑制剂，可阻断A431细胞和MCF10A细胞中的H3K79甲基化。

Technical details

Catalog Num	A12941
M. Wt	618.57
Formula	C28H40BrN7O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1561178-17-3
Synonyms	SGC0946, SGC-0946
SMILES	CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C(=CC4=C3N=CN=C4N)Br)O)O

Biological Activity

SGC 0946是有效的DOT1L甲基转移酶抑制剂，可阻断A431细胞和MCF10A细胞中的H3K79甲基化。

Targets

DOT1L (Cell-free assay)
0.3 nM

Solubility *

In vitro	DMSO	98 mg/mL (158.43 mM)
	Water	Insoluble
	Ethanol	98 mg/mL (158.43 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.17 mL	80.83 mL	161.66 mL
0.5 mM	3.23 mL	16.17 mL	32.33 mL
1 mM	1.62 mL	8.08 mL	16.17 mL
5 mM	0.32 mL	1.62 mL	3.23 mL

*The above data is based on the productmolecular weight 618.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.