Spautin-1

Catalog No. A12942

Spautin-1是一种新型的自噬抑制剂，IM抑制K562细胞的生长，IC50为1.03μM。相反，与Spautin-1共同处理可增加IM诱导的细胞活力抑制，IC50为0.45μM。

Product Citations

Yoon-Jin Kim, .et al. An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system, Sci Adv, 2021, Feb 19;7(8) PMID: 33608268

Technical details

Catalog Num	A12942
M. Wt	271.26
Formula	C15H11F2N3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1262888-28-7
Synonyms	Spautin 1, Spautin1
SMILES	FC1=CC(C(NCC2=CC=C(F)C=C2)=NC=N3)=C3C=C1

Biological Activity

Spautin-1是一种新型的自噬抑制剂，IM抑制K562细胞的生长，IC50为1.03μM。相反，与Spautin-1共同处理可增加IM诱导的细胞活力抑制，IC50为0.45μM。

Targets

USP10	USP10	USP13
0.6 μM	~0.6 μM	~0.6 μM

Solubility *

In vitro	DMSO	51 mg/mL (188.01 mM)
	Water	Insoluble
	Ethanol	7 mg/mL (25.8 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	36.87 mL	184.33 mL	368.65 mL
0.5 mM	7.37 mL	36.87 mL	73.73 mL
1 mM	3.69 mL	18.43 mL	36.87 mL
5 mM	0.74 mL	3.69 mL	7.37 mL

*The above data is based on the productmolecular weight 271.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.