GDC-0623

Catalog No. A12974

GDC-0623是一种有效的ATP竞争性MEK1抑制剂，Ki为0.13 nM。

Technical details

Catalog Num	A12974
M. Wt	456.21
Formula	C16H14FIN4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1168091-68-6
Synonyms	GDC0623, GDC 0632
SMILES	O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=C1)=CN=C3)NOCCO

Biological Activity

GDC-0623是一种有效的ATP竞争性MEK1抑制剂，Ki为0.13 nM。

Targets

MEK1
0.13 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 89 mg/mL (195.08 mM)
	Water	Insoluble
	Ethanol	Warmed: 5 mg/mL (10.95 mM)
In vivo	5% DMSO+45% PEG 300+ddH2O	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.92 mL	109.6 mL	219.2 mL
0.5 mM	4.38 mL	21.92 mL	43.84 mL
1 mM	2.19 mL	10.96 mL	21.92 mL
5 mM	0.44 mL	2.19 mL	4.38 mL

*The above data is based on the productmolecular weight 456.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.