HS-173

Catalog No. A13021

HS-173是一种新型磷脂酰肌醇3激酶（PI3K）抑制剂，通过促进细胞凋亡和抑制血管生成而具有抗肿瘤活性。

Product Citations

Mostafa Khater, .et al. Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK, J Biol Chem, 2021, Jan-Jun, 296:100805 PMID: 34022220
Mostafa Khater, .et al. G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers, J Biol Chem, 2021, Jan 22;296:100325 PMID: 33493514

Technical details

Catalog Num	A13021
M. Wt	422.1
Formula	C21H18N4O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1276110-06-5
Synonyms	HS173
SMILES	CCOC(=O)C1=CN=C2N1C=C(C=C2)C3=CC(=CN=C3)NS(=O)(=O)C4=CC=CC=C4

Biological Activity

HS-173是一种新型磷脂酰肌醇3激酶（PI3K）抑制剂，通过促进细胞凋亡和抑制血管生成而具有抗肿瘤活性。

Targets

PI3Kα
0.8 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 81 mg/mL (191.73 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.69 mL	118.46 mL	236.91 mL
0.5 mM	4.74 mL	23.69 mL	47.38 mL
1 mM	2.37 mL	11.85 mL	23.69 mL
5 mM	0.47 mL	2.37 mL	4.74 mL

*The above data is based on the productmolecular weight 422.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.