CO-1686 (Rociletinib, AVL-301)

Catalog No. A13028

CO-1686是一种新型的口服靶向共价（不可逆）抑制剂，可抑制表皮生长因子受体（EGFR）的致癌突变形式，目前正在研究用于治疗非小细胞肺癌（NSCLC）。

Technical details

Catalog Num	A13028
M. Wt	555.55
Formula	C27H28F3N7O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1374640-70-6
Synonyms	CO1686; AVL-301; CNX-419 ;AVL 301; AVL301; CNX419
SMILES	CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC

Biological Activity

CO-1686是一种新型的口服靶向共价（不可逆）抑制剂，可抑制表皮生长因子受体（EGFR）的致癌突变形式，目前正在研究用于治疗非小细胞肺癌（NSCLC）。

Solubility *

In vitro (25°C)	DMSO	91 mg/mL (163.8 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18 mL	90 mL	180 mL
0.5 mM	3.6 mL	18 mL	36 mL
1 mM	1.8 mL	9 mL	18 mL
5 mM	0.36 mL	1.8 mL	3.6 mL

*The above data is based on the productmolecular weight 555.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

CO-1686 (Rociletinib, AVL-301)

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions