NMS-1286937

Catalog No. A13045

NMS-1286937是一种小分子Polo样激酶1（PLK1）抑制剂，具有潜在的抗肿瘤活性。

Technical details

Catalog Num	A13045
M. Wt	532.52
Formula	C24H27F3N8O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1034616-18-6
Synonyms	NMS1286937, NMS-P937
SMILES	CN1CCN(CC1)C2=CC(=C(C=C2)OC(F)(F)F)NC3=NC=C4CCC5=C(C4=N3)N(N=C5C(=O)N)CCO

Biological Activity

NMS-1286937是一种小分子Polo样激酶1（PLK1）抑制剂，具有潜在的抗肿瘤活性。

Targets

PLK1	PLK2	PLK3
2 nM	>10 μM	>10 μM

Solubility *

In vitro	DMSO	Warmed: 38 mg/mL (71.36 mM)
	Water	Insoluble
	Ethanol	Warmed: 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.78 mL	93.89 mL	187.79 mL
0.5 mM	3.76 mL	18.78 mL	37.56 mL
1 mM	1.88 mL	9.39 mL	18.78 mL
5 mM	0.38 mL	1.88 mL	3.76 mL

*The above data is based on the productmolecular weight 532.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.