AZD2858

Catalog No. A13060

AZD2858是一种选择性GSK-3抑制剂，IC50为68 nM，激活Wnt信号，增加大鼠的骨量。

Technical details

Catalog Num	A13060
M. Wt	453.52
Formula	C21H23N7O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	486424-20-8
Synonyms	AZD-2858, AZD 2858
SMILES	CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C(=O)NC4=CN=CC=C4)N

Biological Activity

AZD2858是一种选择性GSK-3抑制剂，IC50为68 nM，激活Wnt信号，增加大鼠的骨量。

Targets

GSK-3
68 nM

Solubility *

In vitro (25°C)	DMSO	6 mg/mL (13.23 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.05 mL	110.25 mL	220.5 mL
0.5 mM	4.41 mL	22.05 mL	44.1 mL
1 mM	2.2 mL	11.02 mL	22.05 mL
5 mM	0.44 mL	2.2 mL	4.41 mL

*The above data is based on the productmolecular weight 453.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.