SANT-1

Catalog No. A13095

SANT-1是有效的细胞渗透性Sonic刺猬（Shh）信号传导抑制剂；平滑活性的高亲和力拮抗剂（KD = 1.2 nM）。以20 nM的IC50抑制平滑的激动剂作用（在Shh-LIGHT2细胞中）。

Technical details

Catalog Num	A13095
M. Wt	373.5
Formula	C23H27N5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	304909-07-7
Synonyms	SANT 1, SANT1
SMILES	CC1=C(C(=NN1C2=CC=CC=C2)C)/C=N/N3CCN(CC3)CC4=CC=CC=C4

Biological Activity

Targets

Smoothened receptor
1.2 nM(Kd)

Solubility *

In vitro	DMSO	21 mg/mL (56.22 mM)
	Water	Insoluble
	Ethanol	20 mg/mL (53.54 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.77 mL	133.87 mL	267.74 mL
0.5 mM	5.35 mL	26.77 mL	53.55 mL
1 mM	2.68 mL	13.39 mL	26.77 mL
5 mM	0.54 mL	2.68 mL	5.35 mL

*The above data is based on the productmolecular weight 373.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.