PD173955

Catalog No. A13120

PD-173955是src酪氨酸激酶抑制剂。PD173955抑制Bcr-Abl依赖的细胞生长。PD173955显示G（1）中的细胞周期停滞。PD173955在Bcr-Abl的激酶抑制测定中的IC（50）为1-2 nM，在细胞生长测定中，其抑制Bcr-Abl依赖性底物酪氨酸磷酸化。 PD173955抑制试剂盒配体依赖性c-kit自磷酸化（IC（50）=约25 nM）和试剂盒配体依赖性M07e细胞增殖（IC（50）= 40 nM），但对白介素3依赖性（IC （50）= 250 nM）或粒细胞巨噬细胞集落刺激因子（IC（50）= 1 microM）依赖性细胞生长。

Technical details

Catalog Num	A13120
M. Wt	443.35
Formula	C21H16Cl2N4OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	260415-63-2
Synonyms	PD 173955; PD-173955
SMILES	CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC

Biological Activity

Targets

Bcr-Abl	Src
1 nM-2 nM	22 nM

Solubility *

In vitro	DMSO	Warmed: 13 mg/mL (29.32 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.56 mL	112.78 mL	225.56 mL
0.5 mM	4.51 mL	22.56 mL	45.11 mL
1 mM	2.26 mL	11.28 mL	22.56 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

*The above data is based on the productmolecular weight 443.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.