SRPIN340

Catalog No. A13188

SRPIN340是一种细胞可渗透的异烟酰胺，可作为ATP竞争性SRPK1选择性抑制剂（对mSRPK1和mSRPK2分别为IC50 = 0.14和1.8μM），对143种其他激酶的活性大大降低。

Technical details

Catalog Num	A13188
M. Wt	349.4
Formula	C18H18F3N3O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	218156-96-8
Synonyms	SRPIN 340, SRPIN-340
SMILES	C1CCN(CC1)C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=CC=NC=C3

Biological Activity

SRPIN340是一种细胞可渗透的异烟酰胺，可作为ATP竞争性SRPK1选择性抑制剂（对mSRPK1和mSRPK2分别为IC50 = 0.14和1.8μM），对143种其他激酶的活性大大降低。

Targets

SRPK1
0.89 μM(Ki)

Solubility *

In vitro (25°C)	DMSO	67 mg/mL (191.78 mM)
	Water	Insoluble
	Ethanol	67 mg/mL (191.78 mM)
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.62 mL	143.1 mL	286.2 mL
0.5 mM	5.72 mL	28.62 mL	57.24 mL
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL

*The above data is based on the productmolecular weight 349.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.