PD 123319 ditrifluoroacetate

Catalog No. A13201

PD 123319 ditrifluoroacetate是一种有效的，选择性的非肽血管紧张素AT2受体拮抗剂。大鼠肾上腺组织和大脑的IC50值分别为34和210 nM。

Product Citations

Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851

Technical details

Catalog Num	A13201
M. Wt	736.67
Formula	C31H32N4O3.2CF3CO2H
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	130663-39-7
Synonyms	PD123319, PD-123319
SMILES	CC1=C(C=CC(=C1)CN2C=NC3=C2C[C@H](N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C

Biological Activity

PD 123319 ditrifluoroacetate是一种有效的，选择性的非肽血管紧张素AT2受体拮抗剂。大鼠肾上腺组织和大脑的IC50值分别为34和210 nM。

Targets

AT2 receptor
34 nM

Solubility *

In vitro (25°C)	DMSO	87 mg/mL (171.05 mM)
	Water	87 mg/mL (171.05 mM)
	Ethanol	87 mg/mL (171.05 mM)
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.57 mL	67.87 mL	135.75 mL
0.5 mM	2.71 mL	13.57 mL	27.15 mL
1 mM	1.36 mL	6.79 mL	13.57 mL
5 mM	0.27 mL	1.36 mL	2.71 mL

*The above data is based on the productmolecular weight 736.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.