PYR-41

Catalog No. A13254

PYR-41是细胞渗透性不可逆的泛素激活酶（E1）抑制剂（IC50 <10μM）。

Technical details

Catalog Num	A13254
M. Wt	371.3
Formula	C17H13N3O7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	418805-02-4
Synonyms	PYR 41, PYR41
SMILES	CCOC(=O)C1=CC=C(C=C1)N2C(=O)/C(=C\C3=CC=C(O3)[N+](=O)[O-])/C(=O)N2

Biological Activity

PYR-41是细胞渗透性不可逆的泛素激活酶（E1）抑制剂（IC50 <10μM）。

Targets

Ubiquitin-activating Enzyme E1 (Cell-free assay)
<10 μM

Solubility *

In vitro (25°C)	DMSO	72 mg/mL (193.9 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.93 mL	134.66 mL	269.32 mL
0.5 mM	5.39 mL	26.93 mL	53.86 mL
1 mM	2.69 mL	13.47 mL	26.93 mL
5 mM	0.54 mL	2.69 mL	5.39 mL

*The above data is based on the productmolecular weight 371.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.