ARV-771

Catalog No. A13255

ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.

Technical details

Catalog Num	A13255
M. Wt	986.64
Formula	C49H60ClN9O7S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1949837-12-0
Synonyms	ARV771, ARV 771
SMILES	CC(C(C(C1=CC=C(Cl)C=C1)=N[C@@H](CC(NCCOCCCOCC(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C2)[C@@H]2C(N[C@H](C3=CC=C(C(SC=N4)=C4C)C=C3)C)=O)=O)=O)=O)C5=NN=C(C)N65)=C6S7)=C7C

Biological Activity

ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.

Solubility *

In vitro	DMSO	97 mg/mL (98.31 mM)
	Water	Insoluble
	Ethanol	97 mg/mL (98.31 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.14 mL	50.68 mL	101.35 mL
0.5 mM	2.03 mL	10.14 mL	20.27 mL
1 mM	1.01 mL	5.07 mL	10.14 mL
5 mM	0.2 mL	1.01 mL	2.03 mL

*The above data is based on the productmolecular weight 986.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

ARV-771

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions