ETP-46464

Catalog No. A13328

ETP-46464是一种有效的选择性ATR抑制剂，IC50为25 nM。

Product Citations

Fu-Xing Gong, .et al. De-dimerization of PTB is catalyzed by PDI and is involved in the regulation of p53 translation, Nucleic Acids Res, 2021, Sep 20;49(16):9342-9352 PMID: 34403458

Technical details

Catalog Num	A13328
M. Wt	470.52
Formula	C30H22N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1345675-02-6
Synonyms	ETP46464, ETP 46464
SMILES	CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3COC2=O)C5=CC6=CC=CC=C6N=C5

Biological Activity

ETP-46464是一种有效的选择性ATR抑制剂，IC50为25 nM。

Targets

mTOR	ATR	DNA-PK	PI3Kα	ATM
0.6 nM	14 nM	36 nM	170 nM	545 nM

Solubility *

In vitro	DMSO	6 mg/mL (12.75 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.25 mL	106.27 mL	212.53 mL
0.5 mM	4.25 mL	21.25 mL	42.51 mL
1 mM	2.13 mL	10.63 mL	21.25 mL
5 mM	0.43 mL	2.13 mL	4.25 mL

*The above data is based on the productmolecular weight 470.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.